Notice and Invitation Oral Presentation of Dissertation Proposal Department of Bioengineering Volgenau School of Engineering, George Mason University Nate Sutton Bachelor of Science in Biology, Quinnipiac University, 2005 Master of Science in Biomedical Informatics, Arizona State University, 2012 Data-Driven Spiking Neural Network Models To Refine Theories Of Hippocampal Function Friday, July 30, 2021, 2:00-4:00 pm Via Zoom<https://gmu.zoom.us/j/92911863914> All are invited to attend. Committee Dr. Giorgio Ascoli, Dissertation Director Dr. Vasiliki Ikonomidou, Committee Chair Dr. Nathalia Peixoto Dr. David Hamilton Abstract: Computational modeling has contributed to hippocampal research in a wide variety of ways and through a large diversity of approaches, reflecting the many advanced cognitive roles of this brain region. The work in this proposal has a purpose of advancing theories of hippocampal function through providing resources for and modeling of data-driven simulations. Planned work includes the creation of a literature review and knowledge base on spiking neural network models of the hippocampal formation. This knowledge base will offer advanced search options, a variety of statistical reporting, and many types of simulation property annotations including neuron types and anatomical subregions which match those reported on Hippocampome.org. The annotations will also consistently include evidence descriptions that provide details about why they were chosen. A large-scale simulation of spatial navigation is planned, and it will include the investigation of complex navigation dynamics. High-performance computing will be used to support the modeling scale. The integration of several neural properties based on Hippocampome.org data will benefit the biological accuracy of the work. The software will be designed in a way that is modular and can be efficiently customized for future experiments. Specific hypotheses related to how boundary cells communicate with grid cells will be studied. The use of place cells as an intermediary process in the communication will be investigated. Analyses will be made of alterations that the communications make on grid cell neural activities. Evaluations will be made of differences that occur in neural activity when improved neural property representations are added to modeling through the use of Hippocampome.org data.