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Notice and Invitation
Oral Defense of Doctoral Dissertation
The Volgenau School of Engineering, George Mason University

Md Daud H. Khan

Bachelor of Science, George Mason University, 2008
Master of Science, University of Bridgeport, 2015


Evaluating the Role of ER Stress and Nicotine in Cancer Metabolic Pathways
Wednesday, July 24, 2019, 11:00am - 1:00pm
Krasnow, Room 229
All are invited to attend.

Committee
Dr. Remi Veneziano, Chair
Dr. Juan Cebral
Dr. John R. Cressman
Dr. Carolina S. Morales

Abstract


Despite advancements in technology and discovery of several signaling pathways involved in metastasis of breast cancer, interlinking these processes has been a major challenge along with establishing hierarchical importance of each. The involvement of nicotine, though a known carcinogen, in breast cancer metastasis is still unclear due to the non-clinically relevant concentrations being used in most investigations. The exact type of nicotinic acetylcholine receptor (nAChRs) mediating the cellular actions is yet to be determined as various reports yield contradictory claims. Several investigations have reported the ability of nicotine to directly or indirectly induce epithelial-to-mesenchymal transition (EMT), an important process in the metastatic cascade, in certain cancer types. However, its potential role in eliminating endoplasmic reticulum (ER) stress has not been explored. In this investigation, we aim to interlink and establish the hierarchical framework of 2 critical oncogenic pathways, ER stress and EMT, and investigate the potential role of nicotine in facilitating ER stress elimination during chemically induced EMT in breast cancer via 9 nAChRs.