This is the first seminar in our Spring 2015 Bioengineering Seminar Series. Coffee and cookies will be served. J



When: Thursday - January 29th, 2015 @ 1:30 -2:30 PM

Location: ENGR 3507

Speaker: Kristin H. Gilchrist, Ph.D., RTI International

Title: Microelectronics Solutions for Biomedical Applications: From Cells to Patients


Kristin H. Gilchrist, Ph.D. is a research scientist with the Electronics and Applied Physics Division at RTI International. RTI is a non-profit institute providing research and development services to government and commercial clients.  Her areas of technical expertise include semiconductor microfabrication, system integration, and biological signal processing. Her research focuses on applying these technologies to biomedical challenges. As a graduate student she developed a cell-based biosensor utilizing microelectrode array recordings from cardiac cells. At RTI, she has designed and fabricated a real-time, 3D ultrasound imaging catheter using piezoelectric micromachined ultrasound transducer (pMUT) arrays. Currently Dr. Gilchrist leads an NIH-funded project to develop a wearable seizure monitor with caregiver alert for children with epilepsy, and is interested in applying wearable sensor technology to monitor and assess a range of other health and behavior conditions. Dr. Gilchrist received her B.E. in Biomedical and Electrical Engineering from Vanderbilt University and her M.S. and Ph.D. degrees in Electrical Engineering from Stanford University.


Seminar Abstract:

Microelectronics offers enabling approaches for next-generation medical solutions. This seminar will highlight three different technologies which leverage microelectronics to address a range of biomedical research challenges from cellular models to patient monitoring. The first is a biomimetic microfluidic model of the human airway which is being developed for pharmacokinetic and respiratory virus infection studies. The system features a multi-compartment microfluidic device supporting a triple culture of primary cells on porous membranes. The second technology is a real-time 3D ultrasound imaging catheter for interventional cardiology, enabled by a 2D array of piezoelectric micromachined ultrasound transducers (pMUTs) and a novel interconnect strategy.  Design challenges overcome in construction of a fully functional catheter prototype and its testing in a porcine model will be discussed. Lastly, development of a seizure monitor for children with epilepsy will be discussed. The seizure detection is based on elevated activity of the autonomic nervous system during seizures which can be measured with unobtrusive sensors monitoring ECG, movement, and respiration. The goal is to provide a device which is comfortable enough for daily use to alert a caregiver at seizure onset in order to mitigate seizure-related adverse events.


Thank you,



Claudia Borke

Program Administrator

Volgenau School of Engineering, Department of Bioengineering

3800 Nguyen Engineering Building, 1G5

4400 University Drive

Fairfax, VA 22030

Phone: (703) 993-4190

Fax: (703) 993-2077