Title:Microfluidic Platforms for Cell Studies Speaker:
Darwin
R. Reyes, Ph.D., National Institutes of
Standards and Technology

Thursday,
May 1 12pm Engineering
Building, room 3507

Abstract

We
have developed a number of approaches for cell manipulation
spanning from
polyelectrolyte multilayer (PEM) microfluidic patterns to
dielectrophoretic
(DEP) trapping in microfluidic multilayer systems.The electrostatic
interactions between PEMs
and cells have shown excellent results as a “universal glue” for
cell attachment
in our fluid flow field systems.We
have
engineered a hybrid cell adhesive material (hCAM) and integrated
in a
microfluidic system with DEP trapping forces resulting in rapid
cell
adhesion.Moreover, cell
viability and
function were maintained under DEP conditions.This system has also shown promise for the development of
multilayer
microfluidic devices, where cells can be trapped on opposite sides
of a
permeable polyester (PET) membrane that separates two channels
running
perpendicular to each other.These
approaches
can be used for studies such as cell-cell communication, cell
migration and many other applications.

Speaker
Bio

Dr.
Reyes is a principal investigator in the Nanoscale Metrology Group
in the
Semiconductor & Dimensional Metrology Division of the Physical
Measurement
Laboratory (PML) at the National Institute of Standards and
Technology
(NIST).He received his
Ph.D. and B.S.
in chemistry from the University of Puerto Rico.He also received a M.S. in
Applied Biomedical
Engineering from The Johns Hopkins University.His research history covers diverse scientific fields,
i.e., from
toxicology and environmental analytical chemistry, to biomedical
engineering
and microfluidic systems.In
his
doctoral work, he chemically characterized airborne particulate
matter from an
area in Puerto Rico of high incidence of cancer, asthma, and other
respiratory
diseases, using cell-based toxicological assays.After completing his Ph.D. he
was awarded
with a National Science Foundation Postdoctoral Fellowship to work
with
Professor Andreas Manz at Imperial College, London, U.K.During this postdoctoral
experience, he
worked with microfluidic devices in developing two-dimensional
separation
systems and analog computing using glow discharge in microfluidic
chips.

Dr.
Reyes joined NIST as a National Research Council postdoctoral
fellow.There he started
integrating his previous
research experiences in cell-based measurements and microfluidics
with
electronics manipulation and measurements developing
bioelectronics-related
technology.Dr. Reyes has
been
developing microfluidic devices with integrated dielectrophoretic
manipulation
for long-term cell survival, and recently he started working
towards the
development of measurement tools for dynamic forces in
mechanobiology.Overall,
his work has been cited more than
2,700 times.At NIST, his
work has been
funded through various intramural programs including Advanced
Technology
Program (ATP), Director's Reserve Funds, and Innovations in
Measurement Science
(IMS) Program.

Dr.
Reyeswas the co-chair of
the 1st Annual
Diversity Day celebrated at NIST in 2006 and was awarded the NIST
EEO Diversity
Award (2008) for his contribution in organizing that event. He was
also an
executive committee member of the NIST Sigma Xi Chapter.Dr. Reyes is currently a
member of the
Nanoparticle Safety Committee as well as the NIST Biosafety
Committee.

[Adapted
from an email message that I received. SGN]

The
National Science Foundation (NSF) requests recommendations for
membership on
its scientific and technical federal advisory committees. Self
recommendations
are accepted. Committee members serve varying term lengths. NSF
has 13
scientific and technical advisory committees, including:

New
NSF Mathematical Sciences Innovation
Incubator

[Adapted
from an email message that I received. SGN]

The
National Science Foundation (NSF) Division of Mathematical
Sciences (DMS) aims
to enhance the synergistic relationships between the mathematical
sciences and
other NSF-supported disciplines through the Mathematical Sciences
Innovation
Incubator (MSII) activity. The MSII activity encourages and
supports new
research collaborations among mathematical scientists and other
scientists and
engineers working in NSF-supported research areas of high national
priority by:

facilitating
DMS co-review and co-funding of multi-disciplinary research
collaborations
involving mathematical scientists;

providing
leverage for investments of non-DMS NSF programs in projects
that include
mathematical scientists; and

providing
a uniform mechanism through which collaborative research teams
involving mathematical
scientists can request DMS co-review.

The
ideas, tools, and language of mathematics and statistics play
important roles
in every area of science and engineering research supported by the
NSF, and it
is widely recognized that interactions between the mathematical
sciences and
other fields catalyze developments in both.

… The
Division of Mathematical Sciences wishes to foster the
participation of more
mathematical scientists, from every area of mathematics and
statistics, in such
important interdisciplinary work. In support of this goal, the
MSII activity
provides funding to catalyze the involvement of mathematical
scientists in
research areas where the mathematical sciences are not yet playing
large roles.

The
MSII activity will emphasize scientific research areas of high
national
priority that would benefit from innovative developments in
mathematics and
statistics. … Areas of national high-priority scientific research
in fiscal
year 2014 identified by the U.S. Office of Science and Technology
Policy include:

Advanced
Manufacturing

Clean
Energy

Global
Climate Change

Research
and Development for Informed Policy-Making and Management

To
apply for MSII support, after submitting a proposal to a non-DMS
program for a
research project that involves mathematical scientists, or a
supplement request
to include new mathematical scientists in a research project
supported by a
non-DMS award, the Principal Investigator must send an e-mail
message
specifying the name(s) and affiliation(s) of the mathematical
scientist(s) and
the NSF proposal ID to [ [log in to unmask] ]. Transmission of
this e-mail
message will constitute a request that DMS consider the proposal
or supplement
request for MSII funding.

Qilian
Li of the Electrical & Computer Engineering Department
received $50K from
the National Institute of Standards and Technology for his
project, “Two-Dimensional
Atomic Crystal Field
Transistors with Ultra-High Sensitivity.”

--
===============================================================
Stephen G. Nash
Senior Associate Dean
Volgenau School of Engineering
George Mason University
Nguyen Engineering Building, Room 2500
Mailstop 5C8
Fairfax, VA 22030
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Phone: (703) 993-1505
Fax: (703) 993-1633
http://volgenau.gmu.edu/web/volgenau/senior-associate-dean