Stochastic Models for Molecular Motors across Scales
Department of Statistics
Penn State University
Engr Room 4201
4400 University Drive, Fairfax, VA 22030
Time: 10:30 A.M. - 11:30 A.M.
Date: Friday, Jan 31, 2014
Linear molecular motors, such as kinesin and dynein, carry cargo, such as vesicles and organelles, through a cell along a microtubule network. The heads of these motors step along a microtubule and are on the order of nanometers, while the cargo size and the distance traveled can be on the order of hundreds or thousands of nanometers. Stochastic models of motors and motor-cargo complexes that describe both the mechanics and chemical kinetics will be presented. In addition, applications of limit theorems will be used to bridge these spatial and temporal scales along with a description of how data can be incorporated into these models at the various scales. Particular attention will be given to how data at one scale can inform biological mechanisms at other scales.