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*Stochastic Models for Molecular Motors across Scales*


 *John Fricks*


 *Department of Statistics*


 *Penn State University*

*Engr Room 4201*


 *4400 University Drive, Fairfax, VA 22030*


 *Time: 10:30 A.M. - 11:30 A.M.*


 *Date: **Friday**, **Jan 31**, 201**4*

*Abstract*

Linear molecular motors, such as kinesin and dynein, carry cargo, such as
vesicles and organelles, through a cell along a microtubule network. The
heads of these motors step along a microtubule and are on the order of
nanometers, while the cargo size and the distance traveled can be on the
order of hundreds or thousands of nanometers.  Stochastic models of motors
and motor-cargo complexes that describe both the mechanics and chemical
kinetics will be presented.  In addition, applications of limit theorems
will be used to bridge these spatial and temporal scales along with a
description of how data can be incorporated into these models at the
various scales.  Particular attention will be given to how data at one
scale can inform biological mechanisms at other scales.


-- 
Yunpeng Zhao, PhD

Assistant Professor
Department of Statistics
Volgenau School of Engineering <[log in to unmask]>
George Mason University
Engineering Building, Room 1719, MS 4A7
4400 University Drive
Fairfax, VA 22030-4444

Phone: 703-993-1674
Email: [log in to unmask]