Good morning,

Below is information regarding the Colloquium for February 12, 2013.  Dr. Iosif Vaisman will be speaking beginning at 4:30pm in room 256 of Bull Run Hall on the PW campus. 

Please plan to attend.


Begin forwarded message:

From: Jeff Solka <[log in to unmask]>
Date: February 10, 2013 7:51:14 AM EST
To: Tiffany C Sandstrum <[log in to unmask]>
Subject: colloquium speaker for 2/12/13

Protein analysis and engineering using computational mutagenesis. (Iosif Vaisman Ph.D., GMU)
Proteins exhibit a wide range of functional consequences upon mutation. Accurate predictive models for the impact of amino acid substitutions on protein stability and activity provide important insights into protein structure, function, and evolution. Such models are also valuable for the study of the effects on phenotype, and can be used to modify protein properties or design new proteins. This approach is based on the computational mutagenesis technique, which utilizes a four-body, knowledge-based, statistical contact potential and machine learning methods. For any mutation due to a single or multiple amino acid replacement in a protein, the method provides an empirical normalized measure of the ensuing environmental perturbation occurring at every residue position. The predictive mutagenesis models of structure-function relationships provide accurate identification of the positions in protein sequence, where introduced substitutions are likely to result in a protein with desired properties.


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