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> Dissertation Defense Announcement
> To:  The George Mason University Community
>
> *Candidate: Todd W. Hawley
> Program:    PhD Biosciences*
>
> *Date:   Tuesday November 27, 2012
> Time:   11:00 a.m.
> Place:  George Mason University
>            Krasnow Institute Conference Room
>            Fairfax Campus 
> <http://www.gmu.edu/resources/welcome/Directions-to-GMU.html>*
>  
> Committee Chair: Dr.  Yuntao Wu
> Committee members: Dr. Ancha Baranova, Dr. Geraldine Grant, Dr. Harold 
> Morowitz
>
> *Title: "Discovery and Mechanism of Action of Cyclonucleoside Anti-HIV 
> Activity"*
>
> The dissertation is on reserve in the Johnson Center Library, Fairfax 
> campus.
> The doctoral project will not be read at the meeting, but should be 
> read in advance.
>
> All members of the George Mason University community are invited to 
> attend.
>
>
> *ABSTRACT:*
> Over 30 million people worldwide are currently infected with HIV, and 
> even after nearly 30 years of research, an effective cure or vaccine 
> has yet to be found. Given this fact, it is a high priority to 
> discover and develop novel small molecule anti-retrovirals that 
> preferably target cellular proteins or a new step in the HIV life 
> cycle.  With this in mind, a novel anti-HIV drug screen utilizing live 
> virus was developed and used to screen reagents.  A subsequent drug 
> screen led to the discovery of the novel anti-HIV activity of 
> cyclonucleoside compounds.  Further studies revealed that the 
> mechanism of action of these compounds on HIV was likely due to the 
> inhibition of deoxynucleotide metabolic pathways, causing 
> deoxynucleotide pool imbalances leading to lethal mutagenesis in both 
> HIV DNA and RNA synthesis.
>
>  ###