[log in to unmask]" type="cite"> Thesis Defense Announcement
To:  The George Mason University Community

Candidate: Jaimin Patel
Program: Master of Science in Bioinformatics & Computational Biology 

Date:   Wednesday November 28, 2012
Time:   11:00 a.m.
Place:  George Mason University 
	    Bull Run Hall #253
	    Prince William campus
	
 
Thesis Chair: Dr. Daniel N. Cox

Title: "MIAMI: A GRAPHICAL INTERFACE WEB-TOOL FOR INTEGRATED MIRNA-MRNA
INTERACTION ANALYSES IN DROSOPHILA MELANOGASTER"

A copy of the thesis is on reserve in the Johnson Center Library, Fairfax campus.  The thesis will not be read at the meeting, but should be read in advance. All members of the George Mason University community are invited to attend.

ABSTRACT:
This thesis describes the design and implementation of a web-based tool – MIAMI (miRNA and mRNA integrated analysis) – that enables integrative analysis of target predictions, miRNA and gene expression data. MIAMI is divided into two parts: the query section and the analysis section. The query section allows the user to retrieve and browse updated miRNA-mRNA pairs predicted using a number of different computational algorithms such as PITA, miRanda and Target Scan as well as Boolean combinations of these algorithms. The analysis section comprises a multi-step procedure for (i) performing various statistical analyses of mRNA and miRNA expression data; (ii) visualization of networks of the highest confidence miRNA and mRNA interactions and; (iii) retrieval of gene, miRNA and disease-specific information available in several public databases via scientific literature text-mining.

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