To: The George Mason University Community
Candidate: Cshantara L. Woolfolk
Program: Master of Science in Biology
Date: Thursday August 4, 2011
Time: 2:00 p.m.
Place: George Mason University, Prince William campus
Bull Run Hall, Room 247
Thesis Chair: Dr. Emanuel Petricoin
Title: "Evaluation of Patient Characteristics and Clinical Outcomes in Patients Who Have Received
Ventricular Assist Devices"
A copy of the thesis is on reserve
in the Johnson Center
Library, Fairfax campus.
The thesis will not be read at the meeting, but should be
in advance. All members of the George Mason University community are
the United States,
5.3 million people suffer from heart failure. The ventricular assist
a treatment often used for patients suffering from heart failure. This
study sought to
examine patient outcomes over the course of the ventricular assist
program at Inova Heart and Vascular Institute.
The objectives of this
study: 1) Determine the effect of blood products in patients who
ventricular assist devices, 2) Evaluate the effects that decrease in
has had for patients who received ventricular assist devices, and 3)
program improvement and patient outcomes over three consecutive eras
2009, and 2010) of continuous flow ventricular assist devices.
study sample consisted of 138 patients who have received a ventricular
device at Inova Heart and Vascular Institute from January 2006 to May
Primary endpoints were blood product usage, bleeding and adverse events. Several preoperative risk factors were found to be
predictors of RBC and non-RBC product usage, emergency surgery and
fraction. For every unit of non-RBC (OR=1.1, p=0.008)
blood product used, the odds of postoperative death was
increased. With that in mind, there have been significant
improvements in patient adverse events. Postoperative death (within 30
postoperative renal failure, and deaths after thirty days have all
since the beginning of the VAD program. Future endeavors should focus
continuing to improve patient outcomes specifically through decreasing
usage of blood products and controlling for preoperative risk factors.