Thesis Defense Announcement
To: the George Mason Community

Shoaleh Dehghan
Master of Science in Bioinformatics
and Computational Biology

Date: Wednesday December 8, 2010
Time: 11:00 A.M.
Place: Conference Room, #312G
Occoquan Building
Prince William campus

Thesis Chair: Dr. Donald Seto, BCB Dept. 
Title : "Computational Analysis of Pathogen Evolution Using Human Adenovirus Type 4 Genomes"
Comparative genomic and computational analyses of four genomes of human adenovirus type 4 (HAdV-E4), spanning fifty years, document the molecular evolution of this pathogen at the nucleotide level by revealing a recent recombination with HAdV-B within the DNA replication signals in the Inverted Terminal Repeat of two recently circulating isolates.  This, along with an earlier recombination found within the prototype genome that includes the hexon gene of HAdV-B16, apparently allows the current, most virulent isolates to be established in the population.