Thesis Defense Announcement
To: the George Mason Community

*Shoaleh Dehghan
Master of Science in Bioinformatics
and Computational Biology
Date: Wednesday December 8, 2010
Time: 11:00 A.M.
Place: Conference Room, #312G
Occoquan Building
Prince William campus <>
Thesis Chair: Dr. Donald Seto, BCB Dept. 
*Title : *"***Computational Analysis of Pathogen Evolution Using Human 
Adenovirus Type 4 Genomes*"**
Comparative genomic and computational analyses of four genomes of human 
adenovirus type 4 (HAdV-E4), spanning fifty years, document the 
molecular evolution of this pathogen at the nucleotide level by 
revealing a recent recombination with HAdV-B within the DNA replication 
signals in the Inverted Terminal Repeat of two recently circulating 
isolates.  This, along with an earlier recombination found within the 
prototype genome that includes the hexon gene of HAdV-B16, apparently 
allows the current, most virulent isolates to be established in the