Print

Print


*PLEASE NOTE ROOM CHANGE FOR THE DEFENSE*
>> *Dissertation Defense Announcement:
>> To:  The George Mason University Community*
>>
>> *Takako Takeda
>> PhD Bioinformatics Candidate
>> *
>> *Date:   Friday October 22, 2010
>> Time:   10:00 a.m. 
>> Place:  George Mason University
>> ** 	     Room 312-G, Occoquan Bldg.
>> 	     Prince William campus <http://www.gmu.edu/resources/visitors/findex.html>
>>   
>> Dissertation Chair: Dr. Dmitri Klimov
>> Committee members: Dr. Iosif Vaisman, Dr. Estela Blaisten-Barojas, Dr. John Grefenstette*
>>
>> *Title: "Growth of *A? *Amyloid fibrils studied by computer simulations"*
>>
>> A copy of the dissertation is on reserve in the Johnson Center 
>> Library, Fairfax campus.  The doctoral project will not be read at 
>> the meeting, but should be read in advance.
>>
>> All members of the George Mason University community are invited to 
>> attend.*
>> *
>>
>> *ABSTRACT:
>> *
>> Aggregation of A? peptides is related to the onset of Alzheimer's 
>> disease, but the molecular mechanism of A? fibril formation is still 
>> poorly understood. Thermodynamics and energetics of the deposition of 
>> A? monomers on the preformed amyloid fibril were probed by replica 
>> exchange molecular dynamics with implicit solvent model. Consistent 
>> with the experiments the results showed that the fibril growth 
>> follows the dock-lock mechanism. The interactions that stabilize the 
>> binding of the peptide to the fibril and the preferable binding 
>> region in the peptides were identified. Also, a single-site 
>> computational mutation effects on the fibril growth were 
>> investigated. The results indicated that the strong off-registry side 
>> chain interactions may impede fibril growth.
>>
>> ###
>>