Thesis Defense Announcement
To: the George Mason Community
Master of Science in Biology
Date: Thursday November 12, 2009
Time: 2:00 - 4:00 p.m.
Place: Bull Run Hall, Rm 257
Prince William campus
Thesis Chair: Dr. Ancha Baranova, MMB Dept.
Title: C6ORF173 as
an Oncogene Crucial for the Progression of Breast Carcinoma
The genetic mechanism of the
breast carcinoma has been a major topic of research efforts. Previous
studies identified C6ORF173 as part of the small
expression signature differentiating aggressive breast carcinomas with
poor prognoses from relatively indolent Grade 1 tumors. Here we present
data correlating the enhanced expression of C6ORF173
with an increase in in vitro proliferation of both
human breast epithelial cells and human breast carcinoma cells. We have
also shown that overexpression of C6ORF173 leads to an
increase in expression of another gene, FLJ11029
, contributing to the small expression signature, indicative of the
role of C6ORF173 in the orchestration of breast
carcinoma progression. Since C6ORF173
contributes to the aggressive behavior of breast carcinoma tumors, it
can be used in prognostic screens allowing further tailoring of
chemotherapy treatment for this important malignancy.
A copy of the thesis is on reserve in the Johnson
Library, Fairfax campus.
The thesis will not be read at the meeting, but should be
All members of the George Mason University community are invited