Thesis Defense Announcement
To:  The George Mason University Community

Frank Delatour
Master of Science in Biology
Microbiology & Infectious Diseases concentration

Date:   Tuesday June 16, 2009
Time:   2:00 p.m. - 4:00 p.m.
Place:  George Mason University, Prince William campus
	     Bull Run Hall, Room 246
Thesis Chair:  Dr. Monique van Hoek, MMB Dept.

Title: "The Susceptibility of Aggregatibacter actinomycetemcomitans to a variety of Antibiotics and Antimicrobial Peptides"


Actinobacillus actinomycetemcomitans is a Gram-negative bacterium, which is recognized as playing a role in the two most prevalent oral diseases, dental caries and periodontitis. The bacterium tends to inhabit microbial biofilms located in the subgingival dental plaque. This work characterizes the strength and size of the biofilms created by A. actinomycetemcomitans using in vitro experimental techniques. Many of the pathogenic properties of bacteria are able to be created and because of the stable microenvironments created by residence within biofilms. Initially planktonic bacteria are exposed to a variety of antimicrobial agents such as antibiotics and antimicrobial peptides. The most potent antimicrobials were then tested to see the effect they  had on the bacteria which resided in biofilms. This research is critical in the development of a useful therapeutic strategy in preventing dental caries and periodontitis.


A copy of the thesis is on reserve in the Johnson Center Library, Fairfax campus.  The thesis will not be read at the meeting, but should be read in advance.

All members of the George Mason University community are invited to attend.


Diane St

Diane St. Germain

Coordinator, Biology and Biosciences

Graduate Academic Programs

Molecular and Microbiology Dept.

George Mason University

MS 1H8, 10900 University Blvd. Manassas, VA 20110

Phone (703) 993-4263, Fax (703) 993-8976