Frank Delatour Master of Science in Biology Microbiology & Infectious Diseases concentration Date: Tuesday June 16, 2009 Time: 2:00 p.m. - 4:00 p.m. Place: George Mason University, Prince William campus Bull Run Hall, Room 246 Thesis Chair: Dr. Monique van Hoek, MMB Dept. Title: "The Susceptibility of Aggregatibacter actinomycetemcomitans to a variety of Antibiotics and Antimicrobial Peptides"
Actinobacillus actinomycetemcomitans is a Gram-negative bacterium, which is recognized as playing a role in the two most prevalent oral diseases, dental caries and periodontitis. The bacterium tends to inhabit microbial biofilms located in the subgingival dental plaque. This work characterizes the strength and size of the biofilms created by A. actinomycetemcomitans using in vitro experimental techniques. Many of the pathogenic properties of bacteria are able to be created and because of the stable microenvironments created by residence within biofilms. Initially planktonic bacteria are exposed to a variety of antimicrobial agents such as antibiotics and antimicrobial peptides. The most potent antimicrobials were then tested to see the effect they had on the bacteria which resided in biofilms. This research is critical in the development of a useful therapeutic strategy in preventing dental caries and periodontitis.
A copy of the thesis is on reserve in the Johnson Center Library, Fairfax campus. The thesis will not be read at the meeting, but should be read in advance.
All members of the George Mason University community are invited to attend.
Diane St. Germain
Coordinator, Biology and Biosciences
Graduate Academic Programs
Molecular and Microbiology Dept.
Phone (703) 993-4263, Fax (703) 993-8976