*Thesis Defense Announcement
To:  The George Mason University Community*

*Frank Delatour
Master of Science in Biology
Microbiology & Infectious Diseases concentration
*Date:   Tuesday June 16, 2009
Time:   2:00 p.m. - 4:00 p.m.
Place:  George Mason University, Prince William campus
	     Bull Run Hall, Room 246
Thesis Chair:  Dr. Monique van Hoek, MMB Dept.

Title: **"The Susceptibility of Aggregatibacter actinomycetemcomitans to a variety of Antibiotics and Antimicrobial Peptides**"*


/Actinobacillus actinomycetemcomitans/ is a Gram-negative bacterium, 
which is recognized as playing a role in the two most prevalent oral 
diseases, dental caries and periodontitis. The bacterium tends to 
inhabit microbial biofilms located in the subgingival dental plaque. 
This work characterizes the strength and size of the biofilms created by 
/A. actinomycetemcomitans/ using /in vitro/ experimental techniques. 
Many of the pathogenic properties of bacteria are able to be created and 
because of the stable microenvironments created by residence within 
biofilms. Initially planktonic bacteria are exposed to a variety of 
antimicrobial agents such as antibiotics and antimicrobial peptides. The 
most potent antimicrobials were then tested to see the effect they  had 
on the bacteria which resided in biofilms. This research is critical in 
the development of a useful therapeutic strategy in preventing dental 
caries and periodontitis.


*A copy of the thesis is on reserve in the Johnson Center Library, 
Fairfax campus.  The thesis will not be read at the meeting, but should 
be read in advance. *

*All members of the George Mason University community are invited to 



Diane St. Germain

Coordinator, Biology and Biosciences

Graduate Academic Programs**

*Molecular and Microbiology Dept.*

*George** Mason University*

MS 1H8, 10900 University Blvd. Manassas, VA 20110

*Phone* (703) 993-4263, *Fax* (703) 993-8976