March 2014


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Stephen Nash <[log in to unmask]>
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Stephen Nash <[log in to unmask]>
Mon, 17 Mar 2014 09:18:10 -0400
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List of Announcements (details below):

  * Seminar:Bioengineering Dept.:Mar 18, 1pm
  * Seminar:Bioengineering Dept.:Mar 20, 12pm
  * Mark Pullen and Nicholas Clark Receive Funding from Truestone & U.S.

*Seminar:Bioengineering Dept.:Mar 18, 1pm*

/Title:/Microscale Engineering for Regenerative Medicine
/Speaker:/Faculty candidate Dr. James Ankrum

Tuesday, March 18, 2014
1:00 PM
ENGR 3507


In this seminar two platform-technologies that use microscale 
engineering to take advantage of biological phenomena will be presented. 
The first is a technology inspired by the porcupine. North American 
porcupines have quills with microscopic barbs. The barbs contribute to 
adhesion and unexpectedly, dramatically reduced penetration force. The 
dual functions of barbs were reproduced with synthetic quills and 
applied to medical devices including tissue adhesives and needles. The 
second platform is a technology to enhance therapeutic cells. 
Mesenchymal stem cells' (MSC) ability to differentiate into multiple 
lineages, secrete trophic factors, and modulate inflammatory processes 
has made them of clinical interest; however these diverse functions also 
pose challenges in controlling their phenotype. To address this 
challenge a new platform to control the cell phenotype was developed. 
MSCs were found to efficiently internalize microparticles. Incorporation 
of phenol-type altering drugs into the particles allows the platform to 
be tuned to specific applications. Three applications of this platform 
will be discussed including, controlling MSC differentiation, tracking 
cell location, and enhancing MSC's immune-modulatory potency.


James Ankrum, PhD is a Senior Innovation Fellow in the Medical Devices 
Center at the University of Minnesota focused on developing translatable 
medical technologies. He completed his undergraduate training in 
biomedical engineering with a focus on ergonomics and human factors at 
the University of Iowa. With the support of a Churchill Fellowship, he 
went on to complete a Masters in Engineering Design at Cambridge 
University focusing on the impact of design decisions on patient care. 
After completing his masters, James joined Harvard-MIT's Division of 
Health Sciences and Technology to pursue his PhD in Medical Engineering 
and Medical Physics. During his PhD, James worked on a wide variety of 
projects ranging from engineered cell-based therapies, to drug delivery, 
to bio-inspired medical adhesives.  His research focus is on identifying 
unmet clinical needs and establishing collaborations between academia 
and industry to rapidly foster development of new technologies. Of 
particular interest are novel uses of engineered cell-based therapies 
and the design of medical devices that stimulate natural physiological 
processes to promote regeneration of damaged tissue.

*Seminar:Bioengineering Dept.:Mar 20, 12pm*

/Title:/Microfluidic Systems: Platforms for Chemical Analysis and 
Fabrication of Biomimetric Constructs
/Speaker: /Dr. André A. Adams

Thursday, March 20, 2014
12:00 PM
ENGR 3507


The advent of microfluidic systems some two decades ago has culminated 
in the development of an array of smaller, less expensive, more 
sensitive analytical platforms capable of more rapid chemical analyses, 
as well as the facile on-chip chemical synthesis of fibers, particles, 
and tubules that span the macro, micro, and nano scales. The 
characteristic low Reynolds number laminar flows within these systems 
has fostered the production of high aspect ratio microstructures in the 
fabrication of chemical sensors capable of performing in the marine 
environment while quantitating nitroaromatics in the 10 ppt range 
enabling the detection and more precise localization of compromised 
unexploded ordnance on the sea floor. Additionally, my lab seeks to 
tease out the synergies that exist between microfluidic systems, 
biological cells, and chemical synthesis. Rapid kinetics and mild 
reaction conditions of "Click-chemistry" within the low Reynolds number 
flows has been used to form nested concentric flows of various cell 
suspensions protected by innocuous sheath fluids within microsystems. 
This was accomplished by the incorporation of flow altering geometries 
into the microchannels to induce hydrodynamic focusing influenced by 
systemic advection. The resultant flows were photopolymerized in situ 
using low dose UV-A irradiation. Principles of microfluidic systems, 
chemical sensing, click chemistry, and biohybrid materials will be 
presented followed by recent results from our work in these exciting areas.


André A. Adams received his B.S. in Chemistry from Grambling State 
University in 2000.After brief stints at the E.O. Lawrence Berkeley 
National Laboratory and the Dow Chemical Company as an analytical 
chemist, he entered the Department of Chemistry at Louisiana State 
University. He obtained his Ph.D. in Bioanalytical Chemistry in 2008 
under the supervision of Steven Soper. His dissertation research focused 
on the development of systems for rare cell isolation and enumeration 
from complex matrices by exploiting microfluidic platforms and 
immunoaffinity for selective isolation and quantitation. Dr. Adams 
joined the Naval Research Laboratory as a National Research Council 
Postdoctoral Research Associate in 2008, and focused on the development 
of chemical sensing platforms for autonomous underwater vehicles.

In 2011, Dr. Adams became a federal scientist, and initiated research 
programs directed at the development of biohybrid materials using 
microfluidic systems that employ sheath flow in conjunction with on-chip 
click chemistry to create encapsulated cellular constructs. Current 
interests include explorations into sensing, 3D in vitro models, 
biomaterials, complex co-culture, angiogenesis, and anastomosis.

*Mark Pullen and Nicholas Clark Receive Funding from Truestone & U.S. Army*

Mark Pullen and Nicholas Clark of the C4I Center received $17K from 
Truestone, LLC, and the U.S. Army for their project, "AMSO - Intergrated 


Stephen G. Nash
Senior Associate Dean
Volgenau School of Engineering
George Mason University
Nguyen Engineering Building, Room 2500
Mailstop 5C8
Fairfax, VA 22030

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Phone: (703) 993-1505
Fax: (703) 993-1633